We suggest that this can be achieved by examining more step sections of blocks. Therefore these need to be revised in order to pick up micrometastasis which appears to have clinical significance. PMID: 33212474 DOI: 10.5858/arpa.2020-0411-OA Abstract Context. Moreover 20% of patients who had micrometastases in SLN had positive non-SLNs on final histology.įrozen section analysis of SLNs lacks sufficient accuracy to rule out micrometastasis by current protocols. The overall sensitivity and specificity of frozen section analysis of SLN for the detection of macrometastasis was found to be 100% while those for micrometastasis were 33.3% and 100%, respectively. Overall 40% of patients (62/154) were found to be SLN positive on final (paraffin section) histology, out of which 44 demonstrated macrometastases (>2mm) and 18 micrometastases (<2mm). Three levels of each section submitted are examined and the results were compared with further levels on paraffin sections. The SLNs were sectioned at 2 mm intervals and submitted entirely for frozen sections. We performed a retrospective study on 154 patients who underwent SLN biopsy from January 2008 till October 2011. Keywords: Sentinel lymph node isosulphanblue frozen section early breast. 15.7 of the real positive results of sentinel and 62.7 of the real negative and 2 false positives and 20.9 false negative results and 78. SLNB with blue dye only with frozen section should suffice in early breast cancer. The aim of this study was to determine the sensitivity and specificity of intraoperative frozen section analysis of sentinel lymph nodes (SLNs) for the detection of breast cancer micrometastasis and to evaluate the status of non-sentinel lymph nodes (non-SLNs) in those patients subjected to further axillary sampling. In this study, we investigated 102 patients’ stage 1and 2 breast cancer with clinical negative axillary lymph node and candidates for sentinel lymph node biopsy, were placed under investigation. Recent studies showed that both disease free interval and overall survival are significantly affected by the presence of micrometastatic disease. Patients and Methods: Patients with breast cancer and clinically negative axillary were recruited for sentinel lymph node biopsy (SLNB). However, micrometastases are frequently missed on frozen sections. Aim: This study aimed to investigate the accuracy of frozen section (FS) in diagnosis of sentinel lymph node metastasis and to analyze the predictive factors for false-negativity. Several large scale studies confirmed the diagnostic reliability of this method. Intraoperative sentinel lymph node biopsy has now become the standard of care for patients with clinically node negative breast cancer for diagnosis and also in order to determine the need for immediate axillary clearance.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |